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Dual-targeting inhibition of TNFR1 for alleviating rheumatoid arthritis by a novel composite nucleic acid nanodrug

Selective suppression of tumor necrosis factor (TNF) α-TNF receptor 1 (TNFR1) signaling is a potent solution for rheumatoid arthritis (RA). Herein, novel composite nucleic acid nanodrugs that simultaneously restrain TNF α binding and TNFR1 multimerization were designed to reinforce inhibition of TNF...

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Autori principali: Xiaonan Wang, Fanfan Guo, Yi Zhang, Ziyi Wang, Jiaqi Wang, Rongrong Luo, Xiao Chu, Yongxing Zhao, Pengchao Sun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2023-12-01
Serie:International Journal of Pharmaceutics: X
Soggetti:
Aptamer
Anti-inflammatory peptide
Tumor necrosis factor receptor 1
Nanodrug
Rheumatoid arthritis
Accesso online:http://www.sciencedirect.com/science/article/pii/S2590156723000063
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