Acupuncture alleviates hemorrhagic transformation after delayed rt-PA treatment for acute ischemic stroke by regulating the mitophagy-NLRP3 inflammasome pathway

BackgroundThe clinical application of recombinant tissue plasminogen activator (rt-PA) is significantly constrained by hemorrhagic transformation (HT), a common and severe complication following thrombolysis for ischemic stroke. Notably, the mitochondrial injury-mediated NLRP3 inflammasome plays a c...

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Principais autores:	Tao Jiang, Qianqian Liu, Huanhuan Liu, Zheng Huang, Mengning Yang, Peiyan Huang, Yiting Shen, Yangyang Song, Wentao Xu, Xinchang Zhang, Guangxia Ni
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-04-01
coleção:	Frontiers in Neurology
Assuntos:	acupuncture mitophagy NLRP3 inflammasome hemorrhagic transformation rt-PA thrombolysis acute ischemic stroke
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fneur.2025.1533092/full
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