Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside.

The cyclooctadepsipeptide emodepside and its parent compound PF1022A are broad-spectrum nematicidal drugs which are able to eliminate nematodes resistant to other anthelmintics. The mode of action of cyclooctadepsipeptides is only partially understood, but involves the latrophilin Lat-1 receptor and...

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Detalhes bibliográficos

Principais autores:	Daniel Kulke, Georg von Samson-Himmelstjerna, Sandra M Miltsch, Adrian J Wolstenholme, Aaron R Jex, Robin B Gasser, Cristina Ballesteros, Timothy G Geary, Jennifer Keiser, Simon Townson, Achim Harder, Jürgen Krücken
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-12-01
Colecção:	PLoS Neglected Tropical Diseases
Acesso em linha:	https://doi.org/10.1371/journal.pntd.0003401
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