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Safety profile of sikamat virus and its oncolytic potential in leukemic cells and cancer stem cells

Abstract Leukaemia remains a global health concern. The oncotherapy resistance of leukaemia might be due to the existence of cancer stem cell populations. This study investigated the therapeutic potential of Sikamat virus (PRV7S), a Pteropine orthoreovirus, as an oncolytic virus against acute myeloi...

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Detalhes bibliográficos
Principais autores: Zhen Yun Siew, Ghee Khang Ong, Siew Tung Wong, Pooi Pooi Leong, Boon Shing Tan, Chee-Onn Leong, Juita Binti Chupri, Chee-Mun Fang, Kenny Voon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-04-01
coleção:Scientific Reports
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Acesso em linha:https://doi.org/10.1038/s41598-025-96061-z
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