Systematic identification of variant-specific RNA structure-small molecule interactions exemplified by RNA G-quadruplexes

Abstract Individual genetic variations, such as cancer-associated somatic mutations, alter RNA structures, thereby potentially enhancing or inhibiting the binding of RNA-targeting small molecules. However, to date, no approach has been available to identify these variant-specific RNA-small molecule...

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Detalhes bibliográficos

Principais autores:	Emi Miyashita, Kazumitsu Onizuka, Yutong Chen, Hiroki Yoshida, Hina Hatayama, Shunya Ishikawa, Peijie Yan, Takahito Hasegawa, Mamiko Ozawa, Kaho Maeta, Fumi Nagatsugi, Hirohide Saito, Kaoru R. Komatsu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-70097-9
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