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A genome-wide cell-free DNA methylation analysis identifies an episignature associated with metastatic luminal B breast cancer

Breast cancers of the luminal B subtype are frequent tumors with high proliferation and poor prognosis. Epigenetic alterations have been found in breast tumors and in biological fluids. We aimed to profile the cell-free DNA (cfDNA) methylome of metastatic luminal B breast cancer (LBBC) patients usin...

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Autori principali: Aitor Rodriguez-Casanova, Nicolas Costa-Fraga, Clara Castro-Carballeira, Miriam González-Conde, Carmen Abuin, Aida Bao-Caamano, Tomás García-Caballero, Elena Brozos-Vazquez, Carmela Rodriguez-López, Victor Cebey, Patricia Palacios, Juan F. Cueva, Rafael López-López, Clotilde Costa, Angel Díaz-Lagares
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-10-01
Serie:Frontiers in Cell and Developmental Biology
Soggetti:
DNA methylation
EPIC Array
cell-free DNA
liquid biopsy
metastasis
luminal B
Accesso online:https://www.frontiersin.org/articles/10.3389/fcell.2022.1016955/full
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