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DNA methylation and gene expression as determinants of genome-wide cell-free DNA fragmentation

Abstract Circulating cell-free DNA (cfDNA) is emerging as an avenue for cancer detection, but the characteristics of cfDNA fragmentation in the blood are poorly understood. We evaluate the effect of DNA methylation and gene expression on genome-wide cfDNA fragmentation through analysis of 969 indivi...

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Hoofdauteurs: Michaël Noë, Dimitrios Mathios, Akshaya V. Annapragada, Shashikant Koul, Zacharia H. Foda, Jamie E. Medina, Stephen Cristiano, Christopher Cherry, Daniel C. Bruhm, Noushin Niknafs, Vilmos Adleff, Leonardo Ferreira, Hari Easwaran, Stephen Baylin, Jillian Phallen, Robert B. Scharpf, Victor E. Velculescu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2024-08-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-024-50850-8
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