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High prevalence of KRAS and GNAS mutations in pseudomyxoma peritonei underscores opportunities for targeted therapeutic strategies

Pseudomyxoma peritonei (PMP) is a rare, slow-growing cancer with few efficacious treatment options in unresectable cases. Mutations in the KRAS and GNAS oncogenes are common, but the reported frequencies vary greatly, most likely because of low tumor cellularity in peritoneal tumor samples. With tre...

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Main Authors: Torgunrud Annette, Lund-Andersen Christin, Davidson Ben, Nitschke Marcussen Ina Katrine, Larsen Stein G., Dagenborg Vegar, Flatmark Kjersti
Format: Artigo
Language:Inglês
Published: De Gruyter 2025-12-01
Series:Pleura and Peritoneum
Subjects:
pseudomyxoma peritonei
kras mutation
gnas mutation
oncogenes
targeted therapy
Online Access:https://doi.org/10.1515/pp-2025-0034
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