High prevalence of KRAS and GNAS mutations in pseudomyxoma peritonei underscores opportunities for targeted therapeutic strategies

Pseudomyxoma peritonei (PMP) is a rare, slow-growing cancer with few efficacious treatment options in unresectable cases. Mutations in the KRAS and GNAS oncogenes are common, but the reported frequencies vary greatly, most likely because of low tumor cellularity in peritoneal tumor samples. With tre...

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Autori principali:	Torgunrud Annette, Lund-Andersen Christin, Davidson Ben, Nitschke Marcussen Ina Katrine, Larsen Stein G., Dagenborg Vegar, Flatmark Kjersti
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	De Gruyter 2025-12-01
Serie:	Pleura and Peritoneum
Soggetti:	pseudomyxoma peritonei kras mutation gnas mutation oncogenes targeted therapy
Accesso online:	https://doi.org/10.1515/pp-2025-0034
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