Synthesis and in vitro anticancer activity of N-alkyl phosphoramidate monoesters of 3’-azido-3’-deoxythymidine (AZT)

In this study, a series of novel N-alkyl phosphoramidate monoesters of 3’-azido-3’-deoxythymidine (AZT) were synthesized using two methods. The synthesized phosphoramidates 7a–e were evaluated for their cytotoxic activity in three human cancer cell lines (cervical cancer (HeLa), nasopharyngeal cance...

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Principais autores:	Ewa Czajkowska-Wojciechowska, Aleksandra Singh, Roksana Trznadel, Piotr Ruszkowski, Lech Celewicz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Termedia Publishing House 2019-03-01
coleção:	BioTechnologia
Assuntos:	n-alkyl phosphoramidate monoesters of 3’-azido-3’-deoxythymidine cytotoxic activity human cancer cell lines – hela kb mcf-7 normal human cell line – hdf
Acesso em linha:	https://www.termedia.pl/Synthesis-and-in-vitro-anticancer-activity-of-N-alkyl-phosphoramidate-monoesters-of-3-azido-3-deoxythymidine-AZT-,85,35928,1,1.html
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