Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis

Abstract Background Computational mining of useful enzymes and biosynthesis pathways is a powerful strategy for metabolic engineering. Through systematic exploration of all conceivable combinations of enzyme reactions, including both known compounds and those inferred from the chemical structures of...

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Principais autores:	Musashi Takenaka, Kouhei Kamasaka, Kim Daryong, Keiko Tsuchikane, Seiha Miyazawa, Saeko Fujihana, Yoshimi Hori, Christopher J. Vavricka, Akira Hosoyama, Hiroko Kawasaki, Tomokazu Shirai, Michihiro Araki, Akira Nakagawa, Hiromichi Minami, Akihiko Kondo, Tomohisa Hasunuma
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-06-01
Series:	Microbial Cell Factories
Assuntos:	Computational enzyme mining Artificial metabolic pathway Benzylisoquinoline alkaloid production Cytochrome P450 Tyrosine N-monooxygenase 3,4-dihydroxyphenylacetaldoxime
Acceso en liña:	https://doi.org/10.1186/s12934-024-02453-7
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