Synthesis of New Thiazole-Privileged Chalcones as Tubulin Polymerization Inhibitors with Potential Anticancer Activities

A series of novel thiazole-based chalcones were evaluated for their anticancer activity as potential tubulin polymerization inhibitors. In vitro anticancer screening for the thiazole derivatives <b>2a</b>–<b>2p</b> exhibited broad-spectrum antitumor activity against various cancer cell lines particu...

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Autors principals:	Hamada Hashem, Abdelfattah Hassan, Walid M. Abdelmagid, Ahmed G. K. Habib, Mohamed A. A. Abdel-Aal, Ali M. Elshamsy, Amr El Zawily, Ibrahim Taha Radwan, Stefan Bräse, Ahmed S. Abdel-Samea, Safwat M. Rabea
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-08-01
Col·lecció:	Pharmaceuticals
Matèries:	thiazole chalcones anticancer tubulin inhibitors colchicine binding site
Accés en línia:	https://www.mdpi.com/1424-8247/17/9/1154
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