Defining Bedaquiline Susceptibility, Resistance, Cross-Resistance and Associated Genetic Determinants: A Retrospective Cohort Study

Background: Bedaquiline (BDQ) is a novel agent approved for use in combination treatment of multi-drug resistant tuberculosis (MDR-TB). We sought to determine BDQ epidemiological cut-off values (ECVs), define and assess interpretive criteria against putative resistance associated variants (RAVs), mi...

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Detalhes bibliográficos

Principais autores:	Nazir A. Ismail, Shaheed V. Omar, Lavania Joseph, Netricia Govender, Linsay Blows, Farzana Ismail, Hendrik Koornhof, Andries W. Dreyer, Koné Kaniga, Norbert Ndjeka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2018-02-01
coleção:	EBioMedicine
Assuntos:	Tuberculosis Bedaquiline Clofazimine Mic Mutation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352396418300057
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