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ADAM8 silencing suppresses the migration and invasion of fibroblast-like synoviocytes via FSCN1/MAPK cascade in osteoarthritis

Abstract Objective Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) phenotype leads to an imbalance in the synovial inflammatory microenvironment, which accelerates the p...

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Principais autores: Kai Chen, Huaqiang Tao, Pengfei Zhu, Miao Chu, Xueyan Li, Yi Shi, Liyuan Zhang, Yaozeng Xu, Shujun Lv, Lixin Huang, Wei Huang, Dechun Geng
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-01-01
coleção:Arthritis Research & Therapy
Assuntos:
Osteoarthritis
Fibroblast-like synoviocytes
ADAM8
Inflammation
MAPK
Acesso em linha:https://doi.org/10.1186/s13075-023-03238-w
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