ASK-1 activation exacerbates kidney dysfunction via increment of glomerular permeability and accelerates cellular aging in diabetic kidney disease model mice

Abstract Diabetic kidney disease (DKD) is a major disease characterized by early albuminuria and heightened risk of renal deterioration. Increased reactive oxygen species (ROS) production, especially in glomeruli, plays an important role in the progression of DKD. ROS also cause activation of Apopto...

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Principais autores:	Eriko Kajimoto, Hajime Nagasu, Masanobu Takasu, Seiji Kishi, Masafumi Wada, Rie Tatsugawa, Akira Hirano, Tsukasa Iwakura, Reina Umeno, Yoshihisa Wada, Seiji Itano, Hiroyuki Kadoya, Kengo Kidokoro, Tamaki Sasaki, Naoki Kashihara
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2024-11-01
סדרה:	Scientific Reports
גישה מקוונת:	https://doi.org/10.1038/s41598-024-77577-2
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