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In vitro and in vivo characterization of a novel HSV-1 H129 neurotracer recombinant reveals dose-dependent replication and spread dynamics

ABSTRACT Understanding the organization and connectivity of brain circuits has been a major focus of neuroscience for decades, and viral vectors have been commonly utilized to map neural connections in animal models. The alpha-herpesvirus herpes simplex virus 1 (HSV-1) is one of the most studied and...

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Main Authors: Taulima Nua, Eric Velazquez-Rivera, Ilayda Sayin, Jessica C. Ogu, Michele Wu, Xiangmin Xu, Orkide O. Koyuncu
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2026-02-01
Series:Journal of Virology
Subjects:
viral neurotracer
anterograde spread
H129
replication defective HSV-1
Online Access:https://journals.asm.org/doi/10.1128/jvi.02021-25
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