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Enhancing human islet xenotransplant survival and function in diabetic immunocompetent mice through LRH-1/NR5A2 pharmacological activation

The intricate etiology of type 1 diabetes mellitus (T1D), characterized by harmful interactions between the immune system and insulin-producing beta cells, has hindered the development of effective therapies including human islet transplantation, which requires strong immunosuppressants that impair...

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Автори: N. Cobo-Vuilleumier, P. I. Lorenzo, E. Martin Vazquez, L. López Noriega, R. Nano, L. Piemonti, F. Martín, B. R. Gauthier
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2024-09-01
Серія:Frontiers in Immunology
Предмети:
xenotranplantation
human islet
nuclear receptor
LRH-1
NR5A2
pharmacological treatment
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1470881/full
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