In vitro and in vivo stability of a highly efficient long-acting cocaine hydrolase

Abstract It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites. We have designed and discovered a series of highly efficient cocaine hydrolases, including CocH5-Fc(M6) whi...

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Detalhes bibliográficos

Principais autores:	Linyue Shang, Huimei Wei, Jing Deng, Madeline J. Stewart, Johnathan E. LeSaint, Annet Kyomuhangi, Shawn Park, Elise C. Maul, Chang-Guo Zhan, Fang Zheng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-05-01
coleção:	Scientific Reports
Assuntos:	Cocaine abuse Cocaine hydrolase Enzyme therapy Protein stability Pharmacokinetics
Acesso em linha:	https://doi.org/10.1038/s41598-024-61646-7
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