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Validation of CRISPR targeting for proliferation and cytarabine resistance control genes in the acute myeloid leukemia cell line MOLM-13

Acute myeloid leukemia patients with FMS-like tyrosine kinase 3–internal tandem duplications and mixed lineage leukemia–protein AF9 fusion proteins suffer from poor clinical outcomes. The MOLM-13 acute myeloid leukemia cell line harbors both of these abnormalities and is used in CRISPR experiments t...

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Autors principals: Subhash C Prajapati, Nicholas Dunham, Hao Fan, Francine E Garrett-Bakelman
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2022-03-01
Col·lecció:BioTechniques
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Accés en línia:https://www.future-science.com/doi/10.2144/btn-2021-0089
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