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Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity

Abstract APOBEC family members play crucial roles in antiviral restriction. However, certain APOBEC3 (A3) proteins drive harmful hypermutation in humans, contributing to cancer. The cancer-associated A3 proteins are capable of transiting from the cytosol to the nucleus, where they can cause genome m...

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Principais autores: Irene Schwartz, Valentina Budroni, Mathilde Meyenberg, Zuzana Hodakova, Harald Hornegger, Kathrin Hacker, Siegfried Schwartz, Daniel B. Grabarczyk, Julian F. Ehrmann, Sara Scinicariello, David Haselbach, Jörg Menche, Tim Clausen, G. Elif Karagöz, Gijs A. Versteeg
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-01-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-026-68420-5
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