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Heterogeneity of sporadic Parkinson’s disease: molecular approach to solving the problem

We performed search for mutations in the LRRK2, PRKN (parkin)and SNCA (a-synuclein) genes in 359 patients of Slavonic ethnicorigin (169 men and 190 women) with Parkinsons disease, ofwhom 345 represented sporadic cases. Age at the disease onset wasfrom 23 to 84 years, and patients with juvenile parki...

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Principais autores: S. N. Illarioshkin, P. A. Slominsky, M. I. Shadrina, G. Kh. Bagyeva, T. B. Zagorovskaya, E. D. Markova, A. V. Karabanov, V. V. Poleshchuk, E. V. Polevaya, N. V. Fedorova, S. A. Limborskaya, I. A. Ivanova-Smolenskaya
Formato: Artigo
Idioma:Inglês
Publicado em: Research Center of Neurology 2007-03-01
coleção:Анналы клинической и экспериментальной неврологии
Assuntos:
parkinson’s disease
sporadic cases
mutation analysis
genetic heterogeneity
genetic counseling
Acesso em linha:https://annaly-nevrologii.com/journal/pathID/article/viewFile/444/339
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