Development of an HPLC-MS/MS Method for Chiral Separation and Quantitation of (<i>R</i>)- and (<i>S</i>)-Salbutamol and Their Sulfoconjugated Metabolites in Urine to Investigate Stereoselective Sulfonation

The aim of this study was to develop and optimize a chiral HPLC-MS/MS method for quantitative analysis of (<i>R</i>)-/(<i>S</i>)-salbutamol and (<i>R</i>)-/(<i>S</i>)-salbutamol-4′-<i>O</i>-sulfate in human urine to allow for bioanalytical quantitation of the targeted analytes and investigations of...

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Auteurs principaux:	Lukas Corbinian Harps, Annika Lisa Jendretzki, Clemens Alexander Wolf, Ulrich Girreser, Gerhard Wolber, Maria Kristina Parr
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2023-10-01
Collection:	Molecules
Sujets:	enzymatic stereoselectivity molecular docking bioanalysis quality-by-design
Accès en ligne:	https://www.mdpi.com/1420-3049/28/20/7206
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