A SARS-CoV-2 Mpro mutation conferring ensitrelvir resistance paradoxically increases nirmatrelvir susceptibility

Abstract SARS-CoV-2 variants resistant to current antivirals remain a significant threat, particularly in high-risk patients. Although nirmatrelvir and ensitrelvir both target the viral 3CL protease (Mpro), their distinct susceptibility profiles may allow alternative therapeutic approaches. Here, we...

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Detalhes bibliográficos

Principais autores:	Seong Cheol Min, Jin-Ju Seo, Ju Hwan Jeong, Beom Kyu Kim, Ji-Hyun Park, Ju Ryeong Lee, Dong Gyu Lee, Gi Chan Lee, Se Hee An, Yun Hee Baek, Young Ki Choi, Hyunah Choo, Hyo Yong Park, Gyeongmin Kim, Byungsun Jeon, Sang Chul Shin, Min-Suk Song
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-65767-z
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