Regenerating myofiber with activating of TGF-β signaling contributes to macrophage efferocytosis through enhancing Tregs response in inflamed muscle

BackgroundThis study aimed to investigate the role of myofiber-specific TGF-β signaling in the development of muscle inflammation by modulating Treg-cell-mediated macrophage efferocytosis.MethodsCTX-induced muscle injury was performed in the tibialis anterior (TA) of control (TGF-βr2flox/flox) and t...

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Autors principals:	HaiQiang Lan, XiaoTing Jian, ZhaoHong Liao, YangYang Li, QiSen Wang, JingWen Huang, JiJie Hu, Hua Liao
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-04-01
Col·lecció:	Frontiers in Immunology
Matèries:	IL-6 macrophage efferocytosis muscle injury TGF-β signaling Tregs
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1810106/full
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