Customizably designed multibodies neutralize SARS-CoV-2 in a variant-insensitive manner

The COVID-19 pandemic evolves constantly, requiring adaptable solutions to combat emerging SARS-CoV-2 variants. To address this, we created a pentameric scaffold based on a mammalian protein, which can be customized with up to 10 protein binding modules. This molecular scaffold spans roughly 20 nm a...

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Auteurs principaux:	Cecilia Abreu, Claudia Ortega, Natalia Olivero-Deibe, Federico Carrión, Aracelly Gaete-Argel, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Rafaela Milan Bonotto, Alessandro Marcello, Sergio Pantano
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2023-08-01
Collection:	Frontiers in Immunology
Sujets:	entry inhibitor avidity multi-target protein design Omicron coronavirus
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1226880/full
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