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New Applications of JAK/STAT Inhibitors in Pediatrics: Current Use of Ruxolitinib

Janus kinases (JAK) are a family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) that transduce cytokine-mediated signals through the JAK–STAT metabolic pathway. These kinases act by regulating the transcription of specific genes capable of inducing biological responses in several immune cell subse...

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Main Authors: Annalisa Marcuzzi, Erika Rimondi, Elisabetta Melloni, Arianna Gonelli, Antonio Giacomo Grasso, Egidio Barbi, Natalia Maximova
Format: Artigo
Language:Inglês
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
Janus kinase
GVHD
ruxolitinib
pediatrics
cytokines
inflammation
Online Access:https://www.mdpi.com/1424-8247/15/3/374
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