Resveratrol attenuates pulmonary fibrosis by inhibiting alveolar epithelial senescence via targeting SASP-related proteins: an integrated bioinformatics-experimental study

BackgroundPulmonary fibrosis (PF) is a progressive and fatal interstitial lung disease with limited treatment options. Premature senescence of alveolar epithelial type II cells (AT2 cells) plays a critical role in PF pathogenesis. This study aimed to identify natural compounds targeting senescence-r...

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Hlavní autoři:	Biao Zuo, Su Yuan, Chen Luo, Xu-Qin Du, Yong-Can Wu, Li-Peng Shi, Jin-Xin Chen, Bo-Tao Chen, Jie Zhou, Yi Ren
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-11-01
Edice:	Frontiers in Pharmacology
Témata:	bleomycin-induced pulmonary fibrosis in mice resveratrol alveolar epithelial senescence bioinformatics senescence-associated secretory phenotype(SASP)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1680998/full
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