Preparation of (177Lu-DOTA)n-PAMAM-[Nimotuzumab-F(ab’)2] as a Therapeutic Radioimmunoconjugate for EGFR Overexpressed Cancer Treatment

Intact monoclonal antibodies with a high molecular weight tend to have a poor pharmacokinetic profile and tumor penetration, and potential for eliciting host antibody responses. F(ab’)2 fragments smaller than intact monoclonal antibodies that still maintain antigen binding could solve this problem....

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Detalles Bibliográficos

Principais autores:	Titis Sekar Humani, Sutari, Triningsih, Martalena Ramli, Rien Ritawidya, Ratna Dini Haryuni
Formato:	Artigo
Idioma:	Inglês
Publicado:	ITB Journal Publisher 2017-12-01
Series:	Journal of Mathematical and Fundamental Sciences
Assuntos:	dendrimer PAMAM EGFR nimotuzumab-F(ab’)2 pepsin digestion 177Lu-DOTA-PAMAM-[nimotuzumab-F(ab’)2]
Acceso en liña:	http://journals.itb.ac.id/index.php/jmfs/article/view/2375
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