Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage.

<h4>Background</h4>Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against ≥70% of K. pneumoniae infections, could avert ~400,000 cases and ~80,000 deaths annually, mostly in Africa and South Asia. Vaccine formu...

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Auteurs principaux:	Thomas D Stanton, Shaun P Keegan, Jabir A Abdulahi, Anne V Amulele, Matthew Bates, Eva Heinz, Yogesh Hooda, Weiming Hu, Kajal Jain, Samiah Kanwar, Rindidzani Magobo, Courtney P Olwagen, John M Tembo, Tolbert Sonda, Jonathan Strysko, Caroline C Tigoi, Sameen Ahmad Amin, Kyle Bittinger, Jennifer Cornick, Ebenezer Foster-Nyarko, Wilson Gumbi, Aneeta Hotwani, Naveed Iqbal, Steven M Jones, Furqan Kabir, Waqasuddin Khan, Chileshe L Musyani, Carolyn M McGann, Varsha Mittal, Ahmed M Moustafa, Patrick Musicha, James C L Mwansa, Moreka L Ndumba, Erkison E Odih, Donwilliams O Omuoyo, Oliver Pearse, Laura T Phillips, Paul J Planet, Aniqa Abdul Rasool, Charlene M C Rodrigues, Kirsty Sands, Arif M Tanmoy, Erin Theiller, Allan M Zuza, Sulagna Basu, Grace J Chan, Kenneth C Iregbu, Jean-Baptiste Mazarati, Semaria Solomon Alemayehu, Timothy R Walsh, Rabaab Zahra, Angela Dramowski, Sombo Fwoloshi, Appiah-Korang Labi, Lola Madrid, Noah Obeng-Nkrumah, David Ojok, Boaz D Wadugu, Andrew C Whitelaw, Adhisivam Bethou, Anudita Bhargava, Atul Jindal, Ruchi N Nanavati, Priyanka S Prasad, Apurba Sastry, Joveria Q Farooqi, Najia Ghanchi, Fyezah Jehan, Erum Khan, Ramesh K Agarwal, Alexander M Aiken, James A Berkley, Susan E Coffin, Nicholas A Feasey, Nelesh P Govender, Davidson H Hamer, Shabir A Madhi, Muhammad Imran Nisar, Samir K Saha, Senjuti Saha, Mari Jeeva Sankar, Kelly L Wyres, Kathryn E Holt
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2026-01-01
Collection:	PLoS Medicine
Accès en ligne:	https://doi.org/10.1371/journal.pmed.1004879
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