Cardiac DPP-4 inhibition by saxagliptin ameliorates isoproterenol-induced myocardial remodeling and cardiac diastolic dysfunction in rats

Saxagliptin, a potent and selective DPP-4 inhibitor, is characterized by its slow dissociation from DPP-4 and its long half-life and is expected to have a potent tissue membrane-bound DPP-4-inhibitory effect in various tissues. In the present study, we examined the effects of saxagliptin on in situ...

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Detaylı Bibliyografya

Asıl Yazarlar:	Junichi Ikeda, Naoya Kimoto, Tetsuya Kitayama, Shunji Kunori
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Elsevier 2016-09-01
Seri Bilgileri:	Journal of Pharmacological Sciences
Konular:	Dipeptidyl peptidase-4 inhibitor Saxagliptin Myocardial remodeling Cardiac diastolic dysfunction Cardiac dipeptidyl peptidase-4
Online Erişim:	http://www.sciencedirect.com/science/article/pii/S1347861316301165
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