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Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality

The biopharmaceutical market is dominated by monoclonal antibodies, the majority of which are produced in Chinese hamster ovary (CHO) cell lines. Intense cell engineering, in combination with optimization of various process parameters results in increasing product titers. To enable further improveme...

Celý popis

Uloženo v:
Hlavní autoři: Lisa Strasser, Amy Farrell, Jenny T. C. Ho, Kai Scheffler, Ken Cook, Patrick Pankert, Peter Mowlds, Rosa Viner, Barry L. Karger, Jonathan Bones
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021-04-01
Edice:Frontiers in Bioengineering and Biotechnology
Témata:
CHO cells
TMT
proteomic profiling
bioprocess monitoring
protein characterization
SPS-MS3
On-line přístup:https://www.frontiersin.org/articles/10.3389/fbioe.2021.569045/full
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