IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity

Abstract Background IMI2-PainCare-BioPain-RCT2 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on specific compartments of the nociceptive system that could serve to accelerate the future development of analgesics. IMI2-PainCare-B...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Caterina Leone, Giulia Di Stefano, Giuseppe Di Pietro, Petra Bloms-Funke, Irmgard Boesl, Ombretta Caspani, Sonya C. Chapman, Nanna Brix Finnerup, Luis Garcia-Larrea, Tom Li, Marcus Goetz, André Mouraux, Bernhard Pelz, Esther Pogatzki-Zahn, Andreas Schilder, Erik Schnetter, Karin Schubart, Irene Tracey, Inaki F. Troconiz, Hans Van Niel, Jose Miguel Vela Hernandez, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittayer, Keith G. Phillips, Andrea Truini, Rolf-Detlef Treede
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-09-01
coleção:	Trials
Assuntos:	Pain Analgesics PK/PD Spinal cord Biomarkers RIII flexion reflex
Acesso em linha:	https://doi.org/10.1186/s13063-022-06431-5
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!