QR-Code

The Role and Mechanism of Alternative Lengthening of Telomeres in Telomerase-negative Tumors and Senescent Cells

The alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR)-based mechanism that maintains telomere length independently of telomerase by hijacking the canonical double-strand break (DSB) repair machinery. In ALT-positive cells, a RAD51-, MUS81-, and BLM-dependent recombinatio...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: JIA Tong-Xin, XIONG Meng-Jie, HOU Kai-Long, LIU Jia-Hua, ZHANG Hao-Nan, JIA Shu-Ting, LIU Jing
Format: Artigo
Sprache:Chinês
Veröffentlicht: Editorial Office of Progress in Biochemistry and Biophysics 2026-01-01
Schriftenreihe:Shengwu huaxue yu shengwu wuli jinzhan
Schlagworte:
alternative lengthening of telomeres (alt)
telomerase-negative tumors
senescent cells
replication stress
chromatin accessibility
Online-Zugang:https://www.pibb.ac.cn/pibbcn/article/abstract/20250310
Tags: Tag hinzufügen
Keine Tags, Fügen Sie das erste Tag hinzu!

Ähnliche Einträge