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Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage

IntroductionMesenchymal stromal cells (MSCs) have been evaluated as a local therapeutic option to treat osteoarthritis (OA) with conflicting clinical results. Our previous studies have evaluated immune licensing of MSC through activation of Toll-like receptor and cytosolic cGAS-STING pathways, with...

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Principais autores: Peter Linde, Lyndah Chow, Isabella Sabino, Zoë Williams, Renata Impastato, Steven Dow, Lynn Pezzanite
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-08-01
Serier:Frontiers in Bioengineering and Biotechnology
Fag:
osteoarthritis
mesenchymal stromal cell
regenerative therapies
STING
toll-like receptor
pattern recognition receptor
Online adgang:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1605148/full
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