Clinical Scaleup of Humanized AnnA1 Antibody Yielded Unexpected High Reticuloendothelial (RES) Uptake in Mice

Background/Objectives: A mouse antibody directed against truncated Annexin A1 showed high tumor retention in pre-clinical cancer models and was approved by the National Cancer Institute Experimental Therapeutics (NExT) program for humanization and large batch cGMP production for toxicology and clini...

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Autori principali:	Lu Lucy Xu, Satyendra Kumar Singh, Chelsea Nayback, Abdullah Metebi, Dalen Agnew, Tim Buss, Jan Schnitzer, Kurt R. Zinn
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-02-01
Serie:	Antibodies
Soggetti:	reticuloendothelial system mouse model antibody immunotherapy cancer therapeutics toxicity
Accesso online:	https://www.mdpi.com/2073-4468/14/1/14
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