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Dual roles of in situ generated HSP70 in antigen delivery and immunoregulation

IntroductionExtracellular release of inducible HSP70 spurred interests to explore its potential interactions with innate immune systems. Both pro- and anti-inflammatory roles have been reported though the immunostimulatory roles were largely disputed due to the likely use of contaminated HSP70. The...

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Main Authors: Xinliang Kang, Zhuofan Li, Jayachandra Reddy Nakkala, Yibo Li, Labone Akter, Yiwen Zhao, Xinyuan Chen
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2025-10-01
Series:Frontiers in Immunology
Subjects:
HSP70
antigen delivery
immunoregulation
inflammation
radiofrequency adjuvant
immunomodulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1638948/full
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