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Deletion of p38 MAPK in macrophages ameliorates peritoneal fibrosis and inflammation in peritoneal dialysis

Abstract One of the most common causes of peritoneal dialysis withdrawal is ultrafiltration failure which is characterized by peritoneal membrane thickening and fibrosis. Although previous studies have demonstrated the inhibitory effect of p38 MAPK inhibitors on peritoneal fibrosis in mice, it was u...

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Principais autores: Akie Ikushima, Takuya Ishimura, Keita P. Mori, Hiroyuki Yamada, Sayaka Sugioka, Akira Ishii, Naohiro Toda, Shoko Ohno, Yukiko Kato, Takaya Handa, Motoko Yanagita, Hideki Yokoi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-09-01
Serier:Scientific Reports
Fag:
p38 MAPK
Peritoneal dialysis
Fibrosis
Macrophage
Online adgang:https://doi.org/10.1038/s41598-024-71859-5
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