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Bet v 1-displaying elastin-like polypeptide nanoparticles induce a strong humoral and weak CD4+ T-cell response against Bet v 1 in a murine immunogenicity model

There is growing concern about the toxicity of colloidal aluminum salts used as adjuvants in subcutaneous allergen immunotherapy (SCIT). Therefore, alternative adjuvants and delivery systems are being explored to replace alum in SCIT. We applied micellar elastin-like polypeptides (ELPs), a type of s...

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Main Authors: Jolinde van Strien, Hans Warmenhoven, Adrian Logiantara, Max Makurat, Lorenz Aglas, Athanasios Bethanis, Romain Leboux, Leonie van Rijt, J. Andrew MacKay, Johannes W. van Schijndel, Gregory Schneider, René Olsthoorn, Wim Jiskoot, Ronald van Ree, Alexander Kros
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
Bet v 1
nanoparticles
aluminum
hypo-allergenic
elastin-like polypeptide
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1006776/full
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