TNF-α induces cytosolic phospholipase A2 expression in human lung epithelial cells via JNK1/2- and p38 MAPK-dependent AP-1 activation.

BACKGROUND: Cytosolic phospholipase A2 (cPLA2) plays a pivotal role in mediating agonist-induced arachidonic acid (AA) release for prostaglandin (PG) synthesis during inflammation triggered by tumor necrosis factor-α (TNF-α). However, the mechanisms underlying TNF-α-induced cPLA2 expression in human...

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Autori principali:	I-Ta Lee, Chih-Chung Lin, Shin-Ei Cheng, Li-Der Hsiao, Yu-Chun Hsiao, Chuen-Mao Yang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2013-01-01
Serie:	PLoS ONE
Accesso online:	http://europepmc.org/articles/PMC3777958?pdf=render
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