Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.
The Suppressor of Fused (SUFU) protein plays an essential role in the Hedgehog (HH) signaling pathway, by regulation of the GLI transcription factors. Two major isoforms of human SUFU are known, a full-length (SUFU-FL) and a carboxy-terminal truncated (SUFU- ΔC) variant. Even though SUFU- ΔC is expr...
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| Principais autores: | , , , , |
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| 格式: | Artigo |
| 语言: | Inglês |
| 出版: |
Public Library of Science (PLoS)
2012-01-01
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| 丛编: | PLoS ONE |
| 在线阅读: | http://europepmc.org/articles/PMC3362617?pdf=render |
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