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Leishmania donovani infection causes distinct epigenetic DNA methylation changes in host macrophages.

Infection of macrophages by the intracellular protozoan Leishmania leads to down-regulation of a number of macrophage innate host defense mechanisms, thereby allowing parasite survival and replication. The underlying molecular mechanisms involved remain largely unknown. In this study, we assessed ep...

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Autors principals: Alexandra K Marr, Julia L MacIsaac, Ruiwei Jiang, Adriana M Airo, Michael S Kobor, W Robert McMaster
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2014-10-01
Col·lecció:PLoS Pathogens
Accés en línia:https://doi.org/10.1371/journal.ppat.1004419
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