Loss of endothelial ZEB2 in mice attenuates steatosis early during metabolic dysfunction-associated steatotic liver disease

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, features liver sinusoidal endothelial cell (LSEC) alterations with ill-defined driving factors. Zinc-Finger E-Box-binding Homeobox (ZEB)2 in LSECs preserves their specializ...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Wouter Dheedene, Stefaan Verhulst, Louise Demuynck, Bram Callewaert, Willeke de Haan, Stefan Vinckier, Jore Van Wauwe, Petra Vandervoort, Marleen Lox, Mathias Stroobants, Renaud Lavend’homme, Wilfred F. J. van IJcken, Elizabeth A. V. Jones, An Zwijsen, Marc Jacquemin, Leo A. van Grunsven, Kimberly Martinod, Danny Huylebroeck, Eskeatnaf Mulugeta, Aernout Luttun
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-07-01
Serier:	Scientific Reports
Fag:	Liver sinusoidal endothelial cells Metabolic dysfunction-associated steatotic liver disease Peroxisome Proliferator-Activated receptor alpha Zinc-finger E-Box-binding Homeobox 2 Capillarization
Online adgang:	https://doi.org/10.1038/s41598-025-05881-6
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!