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Sirt1 coordinates the mitochondrial UPR and myocellular proteostasis to preserve muscle integrity during muscle atrophy in zebrafish

IntroductionThe decline of mitochondrial homeostasis and proteostasis, the two key cell quality control mechanisms, is the hallmark of aging and age-related diseases. One of the most notable examples is the age-related progressive loss of muscle mass, quality, and strength --a condition known as sar...

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Main Authors: Qing Chen, Yu-Lun Chang, Miao-Wen Hung, Po-Lin Lee, Chen Hsin, Yi-Fan Lin
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mitochondrial dysfunction
mitochondrial homeostasis
muscle atrophy
myocellular proteostasis
proteostasis
SIRT1
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2026.1761278/full
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