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DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer

Abstract Oxaliplatin is effective against colorectal cancer (CRC), but resistance hampers treatment. We found upregulated Dickkopf-1 (DKK1, a secreted protein) in oxaliplatin-resistant (OR) CRC cell lines and DKK1 levels increased by more than 2-fold in approximately 50% of oxaliplatin-resistant CRC...

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Váldodahkkit: Chi-Che Hsieh, Ting-Wei Li, Chun-Chun Li, Shang-Hung Chen, You-Lin Wei, Nai-Jung Chiang, Che-Hung Shen
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Nature Publishing Group 2024-09-01
Ráidu:Oncogenesis
Liŋkkat:https://doi.org/10.1038/s41389-024-00537-y
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