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Sophoridine attenuates osteoarthritis progression: association with suppression of chondrocyte pyroptosis via inhibiting NF-κB signaling pathway

IntroductionOsteoarthritis (OA) is a degenerative musculoskeletal disease characterized by cartilage degradation and inflammation. Sophoridine (SR), a quinolizidine alkaloid from traditional Chinese herbs, has demonstrated anti-inflammatory properties, but its role in OA is unknown.MethodsThe effect...

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Principais autores: Ludan Zhang, Xinyu Xing, Chengcong Zhou, Fangda Fu, Zikun Chen, Chengliang Wu, Hongfeng Ruan, Ming Yue
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-07-01
coleção:Frontiers in Pharmacology
Assuntos:
inflammation
NF-κB
osteoarthritis
pyroptosis
sophoridine
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2026.1861567/full
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