Integrating breast cancer polygenic risk scores at scale in the WISDOM Study: a national randomized personalized screening trial

Abstract Background The Women Informed to Screen Depending On Measures of risk (WISDOM) Study is the first prospective, population-wide application of personalized breast cancer screening. We aim to demonstrate the feasibility of the study’s novel use of polygenic risk scores (PRSs) to tailor screen...

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Autori principali:	Kirkpatrick B. Fergus, Rachel S. Heise, Lisa Madlensky, Allison Fiscalini, Leah Sabacan, Sarah Theiner, Shreya Kapoor, Irene A. Soto, Amie Blanco, Katherine Ross, Deborah Goodman-Gruen, Maren Scheuner, Donglei Hu, Diane Heditsian, Susie Brain, Vignesh A. Arasu, Andrea Kaster, Lisa Chapa, Olufunmilayo I. Olopade, Martin Eklund, Jeffrey A. Tice, Elad Ziv, Laura van ‘t Veer, Laura J. Esserman, Yiwey Shieh, The Athena/WISDOM Network Collaborators and Advocate Partners
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-08-01
Serie:	Genome Medicine
Soggetti:	Polygenic risk scores Breast neoplasms Risk prediction Translational genetics
Accesso online:	https://doi.org/10.1186/s13073-025-01524-7
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