Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth

Alpha-amylase is widely exploited as a drug target for preventing postprandial hyperglycemia in diabetes and other metabolic diseases. Inhibition of this enzyme by plant-derived pregnanes is not fully understood. Herein, we used in vitro, in silico, and in vivo studies to provide further insights in...

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Principais autores:	Oludare M. Ogunyemi, Gideon A. Gyebi, Afolabi Saheed, Jesse Paul, Victoria Nwaneri-Chidozie, Olufunke Olorundare, Joseph Adebayo, Mamoru Koketsu, Nada Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Charles O. Olaiya
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-08-01
coleção:	Frontiers in Molecular Biosciences
Assuntos:	diabetes alpha-amylase G. latifolium phytochemicals pregnanes molecular docking
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.866719/full
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