Viral Small T Oncoproteins Transform Cells by Alleviating Hippo-Pathway-Mediated Inhibition of the YAP Proto-oncogene

Primary human cells can be transformed into tumor cells by a defined set of genetic alterations including telomerase, oncogenic RasV12, and the tumor suppressors p53 and pRb. SV40 small T (ST) is required for anchorage-independent growth in vitro and in vivo. Here, we identify the Hippo tumor suppre...

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Autori principali:	Hung Thanh Nguyen, Xin Hong, Sam Tan, Qingfeng Chen, Lifang Chan, Marc Fivaz, Stephen M. Cohen, P. Mathijs Voorhoeve
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2014-08-01
Serie:	Cell Reports
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124714005646
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