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Exploring Reovirus Plasticity for Improving Its Use as Oncolytic Virus

Reoviruses are non-enveloped viruses with a segmented double stranded RNA genome. In humans, they are not associated with serious disease. Human reoviruses exhibit an inherent preference to replicate in tumor cells, which makes them ideally suited for use in oncolytic virotherapies. Their use as ant...

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Principais autores: Vera Kemp, Rob C. Hoeben, Diana J. M. van den Wollenberg
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2015-12-01
coleção:Viruses
Assuntos:
virotherapy
oncolytic viruses
oncolytic cell killing mechanisms
combination therapy
mammalian orthoreoviruses
Acesso em linha:http://www.mdpi.com/1999-4915/8/1/4
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