TRIM29 inhibits PRRSV replication by targeting nsp11 for degradation

ABSTRACT Ubiquitination plays critical roles in viral infections. This study demonstrates that porcine reproductive and respiratory syndrome virus (PRRSV) endoribonuclease nsp11 undergoes K48-linked polyubiquitination specifically at the conserved catalytic residue lysine 173 (K173) during viral inf...

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Auteurs principaux:	Wei Wen, Zhenghong Xue, Yi Lu, Yuhang Liu, Wenqiang Wang, Zhenbang Zhu, Xiangdong Li
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2025-12-01
Collection:	Journal of Virology
Sujets:	PRRSV nsp11 TRIM29 proteasome degradation endonuclease activity site
Accès en ligne:	https://journals.asm.org/doi/10.1128/jvi.01512-25
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